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You should then prepare your submission package as described above , with the exception of the application form, but including your responses to the required CHM areas for discussion see below and send directly to the Clinical Trials Unit email clintrialhelpline mhra.

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Applications that are received later will be assigned to the next available meeting. We will assess the information provided and may provide feedback on the content and completeness of the data package. Points to consider for trials allowing inclusion of patients previously treated with an Advanced Therapy Medicinal Product identifies the main points to consider when proposing trials of an IMP administered after previous ATMP use.

For the purposes of fee determination, an application supported by quality data for blinding purposes for example, placebo comparator or over-encapsulation remains within the category of applications without an IMPD.

Applications under the Notification Scheme do not incur a fee. Invoices for Clinical Trial Authorisation applications, and Substantial Amendment applications are sent directly to the applicant shortly after a valid submission has been established.

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The covering letter for the application should clearly highlight your Purchase Order PO number where available.

It is the responsibility of the applicant to ensure timely payment of invoices for their submissions. Invoices must be settled on receipt of invoice.

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Penalty fees may be incurred for non-payment, details of the penalties are set out in the Fees Regulations. It has now launched in the US as well, so members can view profiles from people in both countries.

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It is also one of the few dating sites used to connect singles on the latest series of the hit TV show, The Undateables. There are three different levels of membership to the site — free trial, gold and VIP. Members on a trial can view profiles and send a limited number of messages, while those at the other end of the scale with VIP membership have priority listing on the site and are featured on the homepage.

Designed for use by disabled people only, the site tries to create an inclusive atmosphere in which people feel safe to express themselves. Meet Disabled Singles Meet Disabled Singles claims to be the fasting growing co-operative of online dating sites in the world. This essentially means that it is part of a collection of dating sites, so if you sign up, your profile will automatically be visible to a larger audience via other relevant dating websites, not just Meet Disabled Singles.

National identification number

Outsiders Outsiders is a social, peer support and dating club, run by and for disabled people. With a vetting policy, members can be sure that all profiles are genuine, thus allowing users freedom of expression in a safe and secure online environment. Make the most of the Clubhouse by participating in lively Facebook discussions and private communications. If the actual value is not known, an entry may be made on the basis of the information given to HM Land Registry for assessing the fees.

Discounts and incentives Often sellers offer discounts and incentives to prospective buyers. We consider that a discount is a cash sum deducted from the purchase price. A discount may also be referred to as an equity discount, a gifted deposit, a gifted equity or cashback.

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When a property transaction includes a discount, we will deduct the value of the discount from the gross price and enter the net lower price paid in the register. If we are unable to identify the net price, we will request this. Where a consideration includes an incentive, our practice is to enter the gross price. Please see Appendix: examples of discounts and incentives for examples of discounts and incentives.

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Forms of entry when the exact price or value is known The following forms of entry will appear in proprietorship registers. Forms of entry if the value is assessed from the level of fees paid The following forms of entry will appear in proprietorship registers. Length of time the information remains in the register The information will stay in the register until there is a further change of ownership that results in a new price or value entry being made.

A price paid or value stated entry is not misleading just because it is historic as a date is also recorded as part of the register entry.

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An entry will also not be misleading merely because, for example, renovation work has enhanced the value of the property since a sale. Reliability of information The entry is based on the information provided to us. It may not represent the full market value of the property.